Publications

A full list of publications may also be found at PubMedGoogle ScholarORCID and Researchgate.

31: Kreisel K, Engqvist MKM, Kalm J, Thompson LJ, Boström M, Navarrete C, McDonald JP, Larsson E, Woodgate R,Clausen AR; DNA polymerase ηcontributes to genome-wide lagging strand synthesis, Nucleic Acids Research. 2018, gky129. PMID: 30597049.

30: Elliott K, Boström M, Filges S, Lindberg M, Van den Eynden J, Ståhlberg A, Clausen AR, Larsson E. Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers. PLoS Genet. 2018; 14(12):e1007849. PMID: 30586386.

29:Posse V, Al-Behadili A, Uhler JP, Clausen AR, Reyes A, Zeviani M,  Falkenberg M, Gustafsson CM. RNase H1 directs origin-specific initiation of DNA replication in human mitochondria. PLoS Genet. 2019; 15(1):e1007781. PMID: 30605451.

28: Kreisel K, Engqvist MKM, Clausen AR. Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA. J Vis Exp. 2017; 14;(129) PMID: 29286447

27: Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired. Wanrooij PH, Engqvist MKM, Forslund JME, Navarrete C, Nilsson AK, Sedman J, Wanrooij S, Clausen AR, Chabes A. Proc Natl Acad Sci U S A. 2017 Nov 6. pii: 201713085. doi: 10.1073/pnas.1713085114. PMID: 29109257

26: Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing.
Orebaugh CD, Lujan SA, Burkholder AB, Clausen AR, Kunkel TA. Methods Mol Biol. 2018;1672:329-345. doi: 10.1007/978-1-4939-7306-4_23. PMID: 29043634

25: Berglund AK, Navarrete C, Engqvist MK, Hoberg E, Szilagyi Z, Taylor RW, Gustafsson CM, Falkenberg M, Clausen AR. Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA. PLoS Genet. 2017;13(2):e1006628. doi: 10.1371/journal.pgen.1006628. PMID: 28207748.

24: Williams, JS, Clausen AR, Lujan SA, Marjavaara L, Clark AB, Burgers PM, Chabes A, Kunkel TA. Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific. Nat. Struct. Mol. Biol. 2015; 22:291-7. PMID: 25751426.

23: Clausen AR, Lujan SA, Burkholder AB, Orebaugh CD, Williams JS, Clausen MF, Malc EP, Mieczkowski PA, Fargo DC, Smith DJ, Kunkel TA. Tracking DNA replication in vivo using ribonucleotides. Nat. Struct. Mol. Biol. 2015; 22:185-91. PMID: 25622295.

22: Clausen AR, Williams JS, Kunkel TA. Measuring Ribonucleotide Incorporation into DNA In Vitro and In Vivo. Methods Mol Biol. (2015); 1300:123-39. PMID: 25916710.

21: Lujan SA, Clausen AR, Clark AB, MacAlpine HK, MacAlpine DM, Malc, EP, Mieczkowski PA, Burkholder AB, Fargo DC, Gordenin DA, Kunkel TA. Heterogenous polymerase fidelity and mismatch repair bias genome variation and composition. (2015) Genome Res. 24: 1751-64. PMID 25217194

20. Serra I, Conti I, Piskur J, Clausen AR, Munch-Petersen B, Terreni M, Ubiali D (2014). Immobilized Drosophila melanogaster Deoxyribonucleoside Kinase (DmdNK) as a High Performing Biocatalyst for the Synthesis of Purine Arabinonucleotides. (2014) Advanced Synthesis & Catalysis. 356(2-3):563-70. DOI: 10.1002/adsc.201300649.

19: Clausen AR, Mutahir Z, Munch-Petersen B, Piskur J. Plants salvage deoxyribonucleosides in mitochondria. (2014) Nucleosides Nucleotides Nucleic Acids. 33(4-6):291-5. PMID 24940682.

18: Clausen AR, Murray MS, Passer AR, Pedersen LC, Kunkel TA. Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc. Natl. Acad. Sci. U S A. (2013) 110(42):16802-16807. PMID: 24082122.

17: Lujan SA, Williams JS, Clausen AR, Clark AB, Kunkel TA. Evidence that ribonucleotides are signals for mismatch repair of leading strand replication errors. Mol Cell. (2013) 50(3):437-43. PMID: 23603118.

16: Mutahir Z, Clausen AR, Andersson KM, Wisen SM, Munch-Petersen B, Piskur J. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. FEBS J. (2013) 280(6):1531-41. PMID: 23351158.

15: Clausen AR, Zhang S, Burgers PM, Lee MY, Kunkel TA. Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase delta. DNA Repair (Amst). (2013) 2(2):121-7. PMID: 23245697.

14: Clausen AR, Girandon L, Ali A, Knecht W, Rozpedowska E, Sandrini MP, Andreasson E, Munch-Petersen B, Piskur J. Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana. FEBS J. (2012) 279(20):3889-97. PMID: 22897443.

13: Williams JS, Clausen AR, Nick McElhinny SA, Watts BE, Johansson E, Kunkel TA. Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase epsilon. DNA Repair (Amst). (2012) 1;11(8):649-56. PMID: 22682724.

12: Tinta T, Christiansen LS, Konrad A, Liberles DA, Turk V, Munch-Petersen B, Piskur J, Clausen AR. Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine. FEMS Microbiol Lett. (2012) 331(2):120-7. PMID 22462611.

11: Mutahir Z, Larsen NB, Christiansen LS, Andersson KM, Rico R, Wisen SM, Clausen AR, Munch-Petersen B, Piskur J. Characterization of oligomeric and kinetic properties of tomato thymidine kinase 1. Nucleosides Nucleotides Nucleic Acids. (2011) 30(12):1223-6. PMID: 22132978.

10: Clausen AR, Al Meani SA, Piskur J. Pasteurella multocida thymidine kinase 1 efficiently activates pyrimidine nucleoside analogs. Nucleosides Nucleotides Nucleic Acids. (2010) 29(4-6):359-62. PMID: 20544520.

9: Hebrard C, Cros-Perrial E, Clausen AR, Dumontet C, Piskur J, Jordheim LP. Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells. Nucleosides Nucleotides Nucleic Acids. (2009) 28(11):1068-75. PMID: 20183574.

8: Khan Z, Knecht W, Willer M, Rozpedowska E, Kristoffersen P, Clausen AR, Munch-Petersen B, Almqvist PM, Gojkovic Z, Piskur J, Ekstrom TJ. Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy. Neuro Oncol. (2010) 12(6):549-58. PMID: 20154339.

7: Knecht W, Mikkelsen NE, Clausen AR, Willer M, Eklund H, Gojkovic Z, Piskur J. Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine. Biochem Biophys Res Commun. (2009) 382(2):430-3. PMID: 19285960.

6: Clausen AR, Girandon L, Knecht W, Survery S, Andreasson E, Munch-Petersen B, Piskur J. A multisubstrate deoxyribonucleoside kinase from plants. Nucleic Acids Symp Ser (Oxf). (2008) (52):489-90. PMID: 18776467.

5: Sandrini MP, Clausen AR, On SL, Aarestrup FM, Munch-Petersen B, Piskur J. Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner. J Antimicrob Chemother. (2007) 60(3):510-20. PMID: 17615154.

4: Sandrini MP, Shannon O, Clausen AR, Bjorck L, Piskur J. Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria. Antimicrob Agents Chemother. (2007) 51(8):2726-32. PMID: 175226755.

3: Kosinska U, Carnrot C, Sandrini MP, Clausen AR, Wang L, Piskur J, Eriksson S, Eklund H. Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding. FEBS J. (2007) 274(3):727-37. PMID: 17288553.

2: Clausen AR, Matakos A, Sandrini MP, Piskur J. Thymidine kinases in archaea. Nucleosides Nucleotides Nucleic Acids. (2006) 25(9-11):1159-63. PMID: 17065082.

1: Sandrini MP, Clausen AR, Munch-Petersen B, Piskur J. Thymidine kinase diversity in bacteria. Nucleosides Nucleotides Nucleic Acids. (2006;) 25(9-11):1153-8. PMID: 17065081.